[HTML][HTML] Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo
L Wang, B Fang, T Fujiwara, K Krager… - Journal of Biological …, 2018 - ASBMB
Osteoporosis, osteopenia, and pathological bone fractures are frequent complications of
iron-overload conditions such as hereditary hemochromatosis, thalassemia, and sickle cell
disease. Moreover, animal models of iron overload have revealed increased bone
resorption and decreased bone formation. Although systemic iron overload affects multiple
organs and tissues, leading to significant changes on bone modeling and remodeling, the
cell autonomous effects of excessive iron on bone cells remain unknown. Here, to elucidate …
iron-overload conditions such as hereditary hemochromatosis, thalassemia, and sickle cell
disease. Moreover, animal models of iron overload have revealed increased bone
resorption and decreased bone formation. Although systemic iron overload affects multiple
organs and tissues, leading to significant changes on bone modeling and remodeling, the
cell autonomous effects of excessive iron on bone cells remain unknown. Here, to elucidate …
