Fewer genes, more noncoding RNA
JM Claverie - Science, 2005 - science.org
JM Claverie
Science, 2005•science.orgRecent studies showing that most “messenger” RNAs do not encode proteins finally explain
the long-standing discrepancy between the small number of protein-coding genes found in
vertebrate genomes and the much larger and ever-increasing number of polyadenylated
transcripts identified by tag-sampling or microarray-based methods. Exploring the role and
diversity of these numerous noncoding RNAs now constitutes a main challenge in
transcription research.
the long-standing discrepancy between the small number of protein-coding genes found in
vertebrate genomes and the much larger and ever-increasing number of polyadenylated
transcripts identified by tag-sampling or microarray-based methods. Exploring the role and
diversity of these numerous noncoding RNAs now constitutes a main challenge in
transcription research.
Recent studies showing that most “messenger” RNAs do not encode proteins finally explain the long-standing discrepancy between the small number of protein-coding genes found in vertebrate genomes and the much larger and ever-increasing number of polyadenylated transcripts identified by tag-sampling or microarray-based methods. Exploring the role and diversity of these numerous noncoding RNAs now constitutes a main challenge in transcription research.
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