[HTML][HTML] Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood
E Blanco, M Pérez-Andrés, S Arriba-Méndez… - Journal of Allergy and …, 2018 - Elsevier
Background Humoral immunocompetence develops stepwise throughout life and
contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and
neoplasia. Immunoglobulin heavy chain (IgH) isotype serum levels can partly explain such
age-related differences, but their relationship with the IgH isotype distribution within memory
B-cell (MBC) and plasma cell (PCs) compartments remains to be investigated. Objective We
studied the age-related distribution of MBCs and PCs expressing different IgH isotypes in …
contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and
neoplasia. Immunoglobulin heavy chain (IgH) isotype serum levels can partly explain such
age-related differences, but their relationship with the IgH isotype distribution within memory
B-cell (MBC) and plasma cell (PCs) compartments remains to be investigated. Objective We
studied the age-related distribution of MBCs and PCs expressing different IgH isotypes in …
