[HTML][HTML] Murine cytomegalovirus promotes renal allograft inflammation via Th1/17 cells and IL-17A
R Dhital, S Anand, B Graber, Q Zeng… - American Journal of …, 2022 - Elsevier
Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. Allograft
damage in animal models is accelerated by CMV-induced T helper 17 (Th17) cell infiltrates.
However, the mechanisms whereby CMV promotes Th17 cell-mediated pathological organ
inflammation are uncharacterized. Here we demonstrate that murine CMV (MCMV)-induced
intragraft Th17 cells have a Th1/17 phenotype co-expressing IFN-γ and/or TNF-α, but only a
minority of these cells are MCMV specific. Instead, MCMV promotes intragraft expression of …
damage in animal models is accelerated by CMV-induced T helper 17 (Th17) cell infiltrates.
However, the mechanisms whereby CMV promotes Th17 cell-mediated pathological organ
inflammation are uncharacterized. Here we demonstrate that murine CMV (MCMV)-induced
intragraft Th17 cells have a Th1/17 phenotype co-expressing IFN-γ and/or TNF-α, but only a
minority of these cells are MCMV specific. Instead, MCMV promotes intragraft expression of …
