[HTML][HTML] Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis
SL Ashley, CA Wilke, KK Kim, BB Moore - Mucosal immunology, 2017 - Elsevier
Fibrocytes are circulating mesenchymal precursors (CD45+, col 1+) recruited to fibrotic
areas. Fibrocytes secrete profibrotic mediators including periostin; a matricellular protein that
regulates cellular interactions with extracellular matrix (ECM) components. In bleomycin-
induced fibrosis, periostin deficiency in structural or hematopoietic cells limits development
of pulmonary fibrosis. To determine if hematopoietic-derived fibrocytes might secrete soluble
factors to activate structural myofibroblast differentiation, wild-type (WT) fibroblasts were …
areas. Fibrocytes secrete profibrotic mediators including periostin; a matricellular protein that
regulates cellular interactions with extracellular matrix (ECM) components. In bleomycin-
induced fibrosis, periostin deficiency in structural or hematopoietic cells limits development
of pulmonary fibrosis. To determine if hematopoietic-derived fibrocytes might secrete soluble
factors to activate structural myofibroblast differentiation, wild-type (WT) fibroblasts were …
