Emphysema and mechanical stress-induced lung remodeling
Physiology, 2013•journals.physiology.org
Transpulmonary pressure and the mechanical stresses of breathing modulate many
essential cell functions in the lung via mechanotransduction. We review how mechanical
factors could influence the pathogenesis of emphysema. Although the progression of
emphysema has been linked to mechanical rupture, little is known about how these stresses
alter lung remodeling. We present possible new directions and an integrated multiscale view
that may prove useful in finding solutions for this disease.
essential cell functions in the lung via mechanotransduction. We review how mechanical
factors could influence the pathogenesis of emphysema. Although the progression of
emphysema has been linked to mechanical rupture, little is known about how these stresses
alter lung remodeling. We present possible new directions and an integrated multiscale view
that may prove useful in finding solutions for this disease.
Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. We present possible new directions and an integrated multiscale view that may prove useful in finding solutions for this disease.
American Physiological Society