[HTML][HTML] Kv2. 1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3
D Greitzer-Antes, L Xie, T Qin, H Xie, D Zhu… - Journal of Biological …, 2018 - ASBMB
The voltage-dependent K+(K v) channel K v 2.1 is a major delayed rectifier in many
secretory cells, including pancreatic β cells. In addition, K v 2.1 has a direct role in
exocytosis at an undefined step, involving SNARE proteins, that is independent of its ion-
conducting pore function. Here, we elucidated the precise step in exocytosis. We previously
reported that syntaxin-3 (Syn-3) is the key syntaxin that mediates exocytosis of newcomer
secretory granules that spend minimal residence time on the plasma membrane before …
secretory cells, including pancreatic β cells. In addition, K v 2.1 has a direct role in
exocytosis at an undefined step, involving SNARE proteins, that is independent of its ion-
conducting pore function. Here, we elucidated the precise step in exocytosis. We previously
reported that syntaxin-3 (Syn-3) is the key syntaxin that mediates exocytosis of newcomer
secretory granules that spend minimal residence time on the plasma membrane before …