[HTML][HTML] ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells
IX Zhang, J Ren, S Vadrevu, M Raghavan… - Journal of Biological …, 2020 - ASBMB
Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin
secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum
(ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although
many studies have attempted to link ER stress and T2DM, the specific effects of ER stress on
beta-cell function remain incompletely understood. To determine the interrelationship
between ER stress and beta-cell function, here we treated insulin-secreting INS-1 (832/13) …
secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum
(ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although
many studies have attempted to link ER stress and T2DM, the specific effects of ER stress on
beta-cell function remain incompletely understood. To determine the interrelationship
between ER stress and beta-cell function, here we treated insulin-secreting INS-1 (832/13) …